Lab News

Dormant proteasomes - new collaborative pre-print by the Haselbach lab

06 Dec 2024

New pre-print alert!

Not only ribosomes but also proteasomes are kept dormant in zebrafish eggs! Sascha Amann from the Haselbach lab discovered that the protein PITHD1 binds to and inhibits proteasomes. Together with Josef from our lab, they could show that proteasomes in zebrafish eggs are bound by PITHD1 and show reduced activity, contributing to protein stabilization in the egg. We were very happy to have been able to contribute physiological relevance to this very interesting mechanistic story! Big congrats to all authors!

New pre-print on open-source RT-LAMP

19 Nov 2024

New pre-print alert from the LAMP-team - the final piece of work of the team that formed during Covid with its mission goal to develop an open-source molecular diagnostics assay for nucleic acid detection for resource-limited settings. And we succeeded! Not only in developing such an assay with simple home-made enzymes and reagents, but also to show that it can be shipped at room temperature to Africa for reactions performed there. This assay not only works for Covid detection but can also be easily adapted for other nucleic acid-based pathogen detection. This work involved a large international collaboration led by our VBC-based students Martin Matl & Max Kellner and Felix Ansah from the WACCBIP in Accra, Ghana, coordinated by Andi, Julius Brennecke (in Vienna) and Gordon Awandare (in Ghana). Thanks to all contributors and the countless volunteers who helped to make it happen during Covid-times, particularly TrEND (Tom Auer & Lucia Prieto-Godino) for establishing the connection to the WACCBIP and providing funding for the African venture.

Link to the article.

Pauli lab at CSHL Fusion meeting

08 Nov 2024

Members of the Vienna BioCenter, including co-organizer Andi and Pauli lab members Victoria and Johannes as well as Maya Voichek (Brennecke lab, IMBA), had a blast at the first ever CSHL Cell & Membrane Fusion Meeting. Four days filled with exciting science, discussions, fun, laughter and meeting new colleagues and catching up with old friends.

On top of that, Victoria and Maya were awarded with two of the three best talk awards, and best of all, we will be able to come back to CSHL in two years time for the second edition of the CSHL Cell & Membrane Fusion meeting due to the success of its first iteration!

PS: Special credit to Andreas for coming up with the AI-designed cover for the meeting poster and booklet!