Lab News

New pre-print by the Pauli and Calo labs on maternal-zygotic ribosomes

30 Aug 2024

New pre-print alert!

In this collaborative study jointly led by Arish Shah from Eliezer Calo’s lab (MIT) and Frieda Leesch from the Pauli lab, we investigated the previously described maternal-zygotic ribosomal system in zebrafish. We discovered that maternal and somatic subunits are compatible with each other and can form hybrid ribosomes. In addition, we found that maternal-type ribosomes are not only made during oogenesis but are generated in primordial germ cells likely throughout the life of the fish. Thus, the previously described dual ribosomal system extends to the germline of the fish, opening the possibility that it may control germline-specific translation.

Big congrats to all authors!

Summary scheme credit to Frieda (Friederike Leesch, PhD thesis 2023)

Goodbye to our VBC summer student Julen

30 Aug 2024

The summer is coming to an end and unfortunately we had to say goodbye to our VBC summer student Julen Casulleras Alava. Over the past two months, Julen worked with Ida on investigating diapause in different fish species. Ida and Julen formed a fantastic team, diving into this new research direction and performing together the very first experiments exploring translational regulation in our newest model organism, the African turquois killifish!

While we will really miss Julen’s excitement, curiosity and passion for science, we are 100% sure that he will do extremely well whereever his next steps will lead him. Julen, let’s stay in touch, and all the best for your (bright) future!

For more information on the Vienna BioCenter Summer School, check out this website.

Fellowship successes for Ida, Amy and Josef

24 Jun 2024

The past week has brought us the news of not only one but three successes for Pauli lab members in recent fellowship applications:

• Ida secured an EMBO postdoctoral fellowship for studying the molecular mechanism of diapause in killifish;
• Amy was awared a SNF postdoctoral fellowship for investigating age-related changes in developmental competence in zebrafish;
• Josef was awarded a DOC PhD fellowship for studying the mechanism and function of dormant ribosome formation in fish and mammals.

Huge congratulations to all three of you for this amazing feat (picture credit to Benedikt Mandl, IMP)!