The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- A quick, easy and open-source SARS-CoV-2 test | 25 Jul 2020
- Welcome to our interns Mirjam, Lena, and Lorena! | 01 Jul 2020
- HFSP postdoc fellowship for Victoria | 26 Mar 2020
- HFSP Young Investigator Award | 26 Mar 2020
- Quio's Ski7 paper on bioRxiv | 20 Mar 2020
- First virtual Lab Meeting in the books | 18 Mar 2020
- BIF PhD fellowship for Andreas | 17 Mar 2020
- Weintraub Award for Victoria | 03 Mar 2020
- DevStem 2020 at the IST | 28 Feb 2020
- Double success at Marie Curie postdoc fellowships | 07 Feb 2020
- Review on species-specific fertilization | 04 Feb 2020
- Crystal Award for Frieda! | 24 Jan 2020
- Happy New Year | 31 Dec 2019
- Winning picture by Victoria Deneke in MBL image contest | 23 Dec 2019
- Huygens Image prize for Karin Panser | 23 Dec 2019
- SFB grant 'RNA-DECO' funded | 12 Dec 2019
- EMBO postdoc fellowship for Laura | 10 Dec 2019
Pauli Lab September 2019