The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- Lab retreat to Mariazell | 18 Sep 2019
- Congrats to Victoria, runner-up for the Max Birnstiel award | 15 Sep 2019
- Welcome to our new postdoc Victoria | 15 Sep 2019
- Welcome to our new postdoc Laura | 01 Sep 2019
- 10th anniversary of the VBC summer school | 30 Aug 2019
- Zebrafish Course at MBL in Woods Hole | 06 Aug 2019
- June/July = conference time! | 29 Jul 2019
- Bouncer paper highlighted in F1000prime | 05 Jul 2019
- Welcome to James | 01 Jul 2019
- Welcome to Andreas | 15 May 2019
- Good-bye and Welcome | 16 Apr 2019
- Dr. Herberg! | 11 Apr 2019
- Welcome to Anastasia | 15 Mar 2019
- PCF11 paper published in Molecular Cell | 25 Feb 2019
- Dr. Schlumm! | 15 Feb 2019
- Bye bye, Tomas and Lisa | 31 Jan 2019
- Welcome to Benni as a Master student | 02 Jan 2019
Pauli Lab October 2018