The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- Double success at Marie Curie postdoc fellowships | 07 Feb 2020
- Review on species-specific fertilization | 04 Feb 2020
- Crystal Award for Frieda! | 24 Jan 2020
- Happy New Year | 31 Dec 2019
- Winning picture by Victoria Deneke in MBL image contest | 23 Dec 2019
- Huygens Image prize for Karin Panser | 23 Dec 2019
- SFB grant 'RNA-DECO' funded | 12 Dec 2019
- EMBO postdoc fellowship for Laura | 10 Dec 2019
- Lab Xmas outing | 06 Dec 2019
- Gingerbread baking | 01 Dec 2019
- Time to celebrate! | 08 Nov 2019
- ReConnect PhD symposium | 07 Nov 2019
- Dr. Chugunova! | 04 Nov 2019
- SNF postdoc fellowship for Laura | 26 Oct 2019
- VIP2 postdoc fellowship for Anastasia | 22 Oct 2019
- DOC fellowship for Krista | 25 Sep 2019
- Lab retreat to Mariazell | 18 Sep 2019
Pauli Lab September 2019