Pauli Lab - from Fertilization to Cellular Remodelling

Research focus

The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
  2. Translational regulation: We are interested in investigating translational regulation during embryogenesis.
  3. Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.

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Publications …

Science sketch

News ticker

  • HFSP postdoc fellowship for Victoria | 26 Mar 2020
  • HFSP Young Investigator Award | 26 Mar 2020
  • Quio's Ski7 paper on bioRxiv | 20 Mar 2020
  • First virtual Lab Meeting in the books | 18 Mar 2020
  • BIF PhD fellowship for Andreas | 17 Mar 2020
  • Weintraub Award for Victoria | 03 Mar 2020
  • DevStem 2020 at the IST | 28 Feb 2020
  • Double success at Marie Curie postdoc fellowships | 07 Feb 2020
  • Review on species-specific fertilization | 04 Feb 2020
  • Crystal Award for Frieda! | 24 Jan 2020
  • Happy New Year | 31 Dec 2019
  • Winning picture by Victoria Deneke in MBL image contest | 23 Dec 2019
  • Huygens Image prize for Karin Panser | 23 Dec 2019
  • SFB grant 'RNA-DECO' funded | 12 Dec 2019
  • EMBO postdoc fellowship for Laura | 10 Dec 2019
  • Lab Xmas outing | 06 Dec 2019
  • Gingerbread baking | 01 Dec 2019

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About us

Pauli Lab members

Pauli Lab September 2019

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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Funding

* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships