Investigating new regulators of embryogenesis

Research focus

We are interested in the control of embryogenesis. Our focus is on investigating new regulators, which range from short proteins to post-transcriptional control mechanisms.

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players that allow sperm-egg interaction and fusion.
  2. Toddler: How does the short secreted protein Toddler (also called Apela/ELABELA) regulate gastrulation movements?
  3. Translational regulation: We are interested in investigating translational regulation and regulation by translation during embryogenesis.

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various experimental and computational approaches, ranging from genetics, molecular biology, cell biology and biochemistry to live cell imaging and genomics technologies.

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Publications …

Science sketch

News ticker

  • Welcome to Andreas | 15 May 2019
  • Good-bye and Welcome | 16 Apr 2019
  • Dr. Herberg! | 11 Apr 2019
  • Welcome to Anastasia | 15 Mar 2019
  • PCF11 paper published in Molecular Cell | 25 Feb 2019
  • Dr. Schlumm! | 15 Feb 2019
  • Bye bye, Tomas and Lisa | 31 Jan 2019
  • Welcome to Benni as a Master student | 02 Jan 2019
  • Happy New Year | 01 Jan 2019
  • Finding the hidden clues | 11 Dec 2018
  • Andi selected to become an EMBO Young Investigator | 20 Nov 2018
  • Mattias Lauwers and Science Slam Awards for PhD students from the Pauli Lab | 09 Nov 2018
  • VBC PhD Symposium 2018 "Metamorphosis - Transforming Science" | 08 Nov 2018
  • Paper published in Science! | 06 Sep 2018
  • Summer research in Woods Hole | 18 Aug 2018
  • First Pauli lab paper accepted | 03 Aug 2018
  • Fellowship from the Marine Biological Labs (MBL) | 22 May 2018

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About us

Pauli Lab members

Pauli Lab October 2018

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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Funding

* Research Institute of Molecular Pathology (IMP) * FWF START Grant 2017 * HFSP Career Development Award * Boehringer Ingelheim Fonds * Austrian Academy of Sciences (ÖAW) * RNA Society (RNA Salon)