Pauli Lab - from Fertilization to Cellular Remodelling

Research focus

The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
  2. Translational regulation: We are interested in investigating translational regulation during embryogenesis.
  3. Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.

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Publications …

Science sketch

News ticker

  • Lab retreat to Mariazell | 18 Sep 2019
  • Congrats to Victoria, runner-up for the Max Birnstiel award | 15 Sep 2019
  • Welcome to our new postdoc Victoria | 15 Sep 2019
  • Welcome to our new postdoc Laura | 01 Sep 2019
  • 10th anniversary of the VBC summer school | 30 Aug 2019
  • Zebrafish Course at MBL in Woods Hole | 06 Aug 2019
  • June/July = conference time! | 29 Jul 2019
  • Bouncer paper highlighted in F1000prime | 05 Jul 2019
  • Welcome to James | 01 Jul 2019
  • Welcome to Andreas | 15 May 2019
  • Good-bye and Welcome | 16 Apr 2019
  • Dr. Herberg! | 11 Apr 2019
  • Welcome to Anastasia | 15 Mar 2019
  • PCF11 paper published in Molecular Cell | 25 Feb 2019
  • Dr. Schlumm! | 15 Feb 2019
  • Bye bye, Tomas and Lisa | 31 Jan 2019
  • Welcome to Benni as a Master student | 02 Jan 2019

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About us

Pauli Lab members

Pauli Lab October 2018

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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Funding

* Research Institute of Molecular Pathology (IMP) * FWF START Grant 2017 * HFSP Career Development Award * Boehringer Ingelheim Fonds * Austrian Academy of Sciences (ÖAW) * RNA Society (RNA Salon)