Investigating new regulators of embryogenesis

Research focus

We are interested in the control of embryogenesis. Our focus is on investigating new regulators, which range from short proteins to post-transcriptional control mechanisms.

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players that allow sperm-egg interaction and fusion.
  2. Toddler: How does the short secreted protein Toddler (also called Apela/ELABELA) regulate gastrulation movements?
  3. Translational regulation: We are interested in investigating translational regulation and regulation by translation during embryogenesis.

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various experimental and computational approaches, ranging from genetics, molecular biology, cell biology and biochemistry to live cell imaging and genomics technologies.

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Publications …

Lab news

Welcome to Friederike

01 Apr 2018

Welcome to Friederike, a former PhD student in Alipasha Vaziri’s lab at the IMP!

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Welcome to Lisa

15 Feb 2018

Welcome to Lisa, the newest addition to the Pauli lab crew. Lisa has joined us as a Master student - welcome on board!

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Visit to Haus des Meeres

20 Jan 2018

The Pauli lab was treated to an in-depth tour of the Haus des Meeres given by the deputy director and curator, Daniel Abed-Navandi. He taught us a lot about the different species on display, and gave us a behind-the-scenes look of how the aquarium operates. Some of the cool organisms we were able to see included a poisonous cone snail species, lots of little jellyfish, and the aquarium’s thriving seahorse population.

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About us

Pauli Lab members

Pauli Lab February 2018

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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Funding

* Research Institute of Molecular Pathology (IMP) * FWF START Grant 2017 * HFSP Career Development Award * Boehringer Ingelheim Fonds * Austrian Academy of Sciences (ÖAW) * RNA Society (RNA Salon)