We are interested in the control of embryogenesis. Our focus is on investigating new regulators, which range from short proteins to post-transcriptional control mechanisms.
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players that allow sperm-egg interaction and fusion.
- Toddler: How does the short secreted protein Toddler (also called Apela/ELABELA) regulate gastrulation movements?
- Translational regulation: We are interested in investigating translational regulation and regulation by translation during embryogenesis.
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various experimental and computational approaches, ranging from genetics, molecular biology, cell biology and biochemistry to live cell imaging and genomics technologies.
Visit to Haus des Meeres
20 Jan 2018
The Pauli lab was treated to an in-depth tour of the Haus des Meeres given by the deputy director and curator, Daniel Abed-Navandi. He taught us a lot about the different species on display, and gave us a behind-the-scenes look of how the aquarium operates. Some of the cool organisms we were able to see included a poisonous cone snail species, lots of little jellyfish, and the aquarium’s thriving seahorse population.
Be(er) (h)our guest
12 Jan 2018
Once upon a time at the IMP…
On the 12th of January, the Pauli lab turned the IMP into a whole new world when holding their Disney-themed beer hour. With princesses on cupcakes and a magical potion from Merlin’s cauldron, everyone gathered for the evening and enjoyed the bare necessities of life. Hakuna matata!
IMP & IMBA Christmas Party
21 Dec 2017
Despite adverse weather conditions everyone who made it to the Ice-Skating ring for the IMP & IMBA Xmas party had a great time. Merry Christmas and Happy Holidays from the Pauli lab!
Pauli Lab February 2018