Investigating new regulators of embryogenesis

Research focus

We are interested in the control of embryogenesis. Our focus is on investigating new regulators, which range from short proteins to post-transcriptional control mechanisms.

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players that allow sperm-egg interaction and fusion.
  2. Toddler: How does the short secreted protein Toddler (also called Apela/ELABELA) regulate gastrulation movements?
  3. Translational regulation: We are interested in investigating translational regulation and regulation by translation during embryogenesis.

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various experimental and computational approaches, ranging from genetics, molecular biology, cell biology and biochemistry to live cell imaging and genomics technologies.

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Publications …

Lab news

Visit to Haus des Meeres

20 Jan 2018

The Pauli lab was treated to an in-depth tour of the Haus des Meeres given by the deputy director and curator, Daniel Abed-Navandi. He taught us a lot about the different species on display, and gave us a behind-the-scenes look of how the aquarium operates. Some of the cool organisms we were able to see included a poisonous cone snail species, lots of little jellyfish, and the aquarium’s thriving seahorse population.

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Be(er) (h)our guest

12 Jan 2018

Once upon a time at the IMP…

On the 12th of January, the Pauli lab turned the IMP into a whole new world when holding their Disney-themed beer hour. With princesses on cupcakes and a magical potion from Merlin’s cauldron, everyone gathered for the evening and enjoyed the bare necessities of life. Hakuna matata!

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IMP & IMBA Christmas Party

21 Dec 2017

Despite adverse weather conditions everyone who made it to the Ice-Skating ring for the IMP & IMBA Xmas party had a great time. Merry Christmas and Happy Holidays from the Pauli lab!

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About us

Pauli Lab members

Pauli Lab February 2018

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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* Research Institute of Molecular Pathology (IMP) * FWF START Grant 2017 * HFSP Career Development Award * Boehringer Ingelheim Fonds * Austrian Academy of Sciences (ÖAW) * RNA Society (RNA Salon)