Lab News

EMBO fellowship for Amy

17 Dec 2024

And just in time before the end of the year we received the fantastic news that our postdoc Amy has secured an EMBO postdoctoral fellowship for investigating how maternal age impacts embryonic development, using zebrafish as a model system. We are very curious to see what Amy will find out about this interesting new topic in our lab!

A big round of applause for Amy for securing this prestigious fellowship!

If you want to know more, here is a link to a news article about the award announcement.

Pre-print alert - Investigating species-specific behavior of Bouncer's receptor on sperm

16 Dec 2024

And here the final paper-alert from the Pauli lab for 2024:

Andreas’s pre-print is out!

Andreas investigated sperm-egg compatibility in fish with a specific focus on Bouncer’s receptor on sperm, particular Izumo1 and Spaca6. Given our prior knowledge on the species-specific behavior of Bouncer in medaka and zebrafish, our initial expectation was that either Izumo1 and/or Spaca6 would behave similarly. However, biology is often more complicated ;-), and Andreas’s unexpected findings underscore the nuanced interplay between molecular restrictions and compatibilities during sperm-egg interaction across teleosts. As Andreas very nicely wrote in the discussion, “a picture of evolutionarily constrained sperm proteins and a more flexible egg protein emerges.”

Interested in knowing more? Check out Andreas’s pre-print here!

Big congrats to Andreas for leading all the work and write-up from start to end!

Dormant proteasomes - new collaborative pre-print by the Haselbach lab

06 Dec 2024

New pre-print alert!

Not only ribosomes but also proteasomes are kept dormant in zebrafish eggs! Sascha Amann from the Haselbach lab discovered that the protein PITHD1 binds to and inhibits proteasomes. Together with Josef from our lab, they could show that proteasomes in zebrafish eggs are bound by PITHD1 and show reduced activity, contributing to protein stabilization in the egg. We were very happy to have been able to contribute physiological relevance to this very interesting mechanistic story. If you are interested in reading more, check-out the pre-print here!

Big congrats to all authors!