New pre-print by the Pauli and Calo labs on maternal-zygotic ribosomes
30 Aug 2024
New pre-print alert!
In this collaborative study jointly led by Arish Shah from Eliezer Calo’s lab (MIT) and Frieda Leesch from the Pauli lab, we investigated the previously described maternal-zygotic ribosomal system in zebrafish. We discovered that maternal and somatic subunits are compatible with each other and can form hybrid ribosomes. In addition, we found that maternal-type ribosomes are not only made during oogenesis but are generated in primordial germ cells likely throughout the life of the fish. Thus, the previously described dual ribosomal system extends to the germline of the fish, opening the possibility that it may control germline-specific translation.
Big congrats to all authors!
Summary scheme credit to Frieda (Friederike Leesch, PhD thesis 2023)