Research focus
The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Dormancy: We are interested in investigating the mechanisms of dormancy in the egg and during embryogenesis, with a particular focus on translational regulation.
Our approach
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
News ticker
- EMBO fellowship for Amy | 17 Dec 2024
- Pre-print alert - Investigating species-specific behavior of Bouncer's receptor on sperm | 16 Dec 2024
- Dormant proteasomes - new collaborative pre-print by the Haselbach lab | 06 Dec 2024
- New pre-print on open-source RT-LAMP | 19 Nov 2024
- Pauli lab at CSHL Fusion meeting | 08 Nov 2024
- ESPRIT grant for Victoria | 29 Oct 2024
- Paper published in Cell - a conserved fertilization complex bridges sperm and egg | 17 Oct 2024
- Bye-bye to Isa and Theresa | 27 Sep 2024
- Pauli lab at CSHL Translation meeting | 05 Sep 2024
- New pre-print by the Pauli and Calo labs on maternal-zygotic ribosomes | 30 Aug 2024
- Goodbye to our VBC summer student Julen | 30 Aug 2024
- Fellowship successes for Ida, Amy and Josef | 24 Jun 2024
- Otto Hahn Medal and Otto Hahn Award for Ida | 12 Jun 2024
- New pre-print by Anastasia on mitochondrial activation during embryogenesis | 11 Jun 2024
- Presentation award for Andreas at the YEN meeting | 28 May 2024
- Laura's review on mRNA dormancy | 20 Mar 2024
- Welcome to Jörg | 01 Mar 2024
About us
Pauli Lab May 2022
Contact us
The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).
Links
Science sketch and videos
Funding
* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships
