Pauli Lab - from Fertilization to Cellular Remodelling

Research focus

The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
  2. Translational regulation: We are interested in investigating translational regulation during embryogenesis.
  3. Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.

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Publications …

Science sketch

News ticker

  • SPACA4 paper published in PNAS | 24 Sep 2021
  • All the best to Eduardo | 31 Aug 2021
  • Goodbye to our VBC summer student Mireia | 30 Aug 2021
  • Annual Review about Sperm-Egg Fusion | 26 Jul 2021
  • Salvadoran internship program in the Pauli lab | 21 Jul 2021
  • Welcome to Mireia, our VBC Summer Student | 01 Jul 2021
  • Christine Beattie Award from IZFS for Jessica | 22 Jun 2021
  • BBQ at Andi's | 21 Jun 2021
  • Andi elected as EMBO Member | 08 Jun 2021
  • First post-Covid-lockdown drinks | 04 Jun 2021
  • 1st Prize PhD student talk for Frieda at MicroSymposium | 23 Apr 2021
  • Jessica's review on self-organized cell migration published in Development | 06 Apr 2021
  • Spring is here! | 31 Mar 2021
  • Bye-bye to Anna | 31 Mar 2021
  • Welcome to Ziya | 01 Mar 2021
  • Quio's Ski7 paper accepted in PlosGenetics | 18 Feb 2021
  • Anna got into Oxford University for her PhD! | 05 Feb 2021

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About us

Pauli Lab members

Pauli Lab June 2021

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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Funding

* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships