Pauli Lab - from Fertilization to Cellular Remodelling

Research focus

The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
  2. Translational regulation: We are interested in investigating translational regulation during embryogenesis.
  3. Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.

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Publications …

Science sketch

News ticker

  • A very Happy New Year! | 31 Dec 2023
  • Talents-for-Future Minisymposium & Iceskating | 29 Dec 2023
  • Good bye to Marcus | 21 Dec 2023
  • Laura's paper published in EMBO Reports | 16 Dec 2023
  • IMP/IMBA Christmas party | 12 Dec 2023
  • Escape room and Christmas dinner | 28 Nov 2023
  • Lauwers Award for best Monday seminar to Josef | 10 Nov 2023
  • Pumpkin carving & Halloween! | 31 Oct 2023
  • Welcome to our Talents-for-Future 'Summer' student Sarah | 15 Oct 2023
  • Rabitsch Award to Frieda | 05 Oct 2023
  • Welcome to Johannes | 01 Oct 2023
  • Collaborative paper on DNA methylation in zebrafish-medaka hybrids published in NAR | 26 Aug 2023
  • Frieda defends her PhD | 25 Aug 2023
  • Catch-up in Woods Hole | 29 Jul 2023
  • New pre-print by Victoria & Andreas on sperm fertilization factors forming a trimer | 29 Jul 2023
  • Pauli lab at the GRC Fertilization | 25 Jul 2023
  • Krista defends her PhD | 19 Jun 2023

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About us

Pauli Lab members

Pauli Lab May 2022

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Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

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Funding

* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships