Research focus
The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
Our approach
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
Science sketch
News ticker
- New pre-print by the Pauli and Calo labs on maternal-zygotic ribosomes | 30 Aug 2024
- Goodbye to our VBC summer student Julen | 30 Aug 2024
- Fellowship successes for Ida, Amy and Josef | 24 Jun 2024
- Otto Hahn Medal and Otto Hahn Award for Ida | 12 Jun 2024
- New pre-print by Anastasia on mitochondrial activation during embryogenesis | 11 Jun 2024
- Presentation award for Andreas at the YEN meeting | 28 May 2024
- Laura's review on mRNA dormancy | 20 Mar 2024
- Welcome to Jörg | 01 Mar 2024
- DevStem Symposium 2024 | 01 Mar 2024
- Welcome to Amy | 01 Mar 2024
- Iceskating in front of the Vienna City Hall | 21 Feb 2024
- Welcome to Ida | 01 Feb 2024
- A very Happy New Year! | 31 Dec 2023
- Talents-for-Future Minisymposium & Iceskating | 29 Dec 2023
- Good bye to Marcus | 21 Dec 2023
- Laura's paper published in EMBO Reports | 16 Dec 2023
- IMP/IMBA Christmas party | 12 Dec 2023
About us
Pauli Lab May 2022
Contact us
The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).
Links
Funding
* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships
