The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- Jessica's review on self-organized cell migration published in Development | 06 Apr 2021
- Spring is here! | 31 Mar 2021
- Bye-bye to Anna | 31 Mar 2021
- Welcome to Ziya | 01 Mar 2021
- Quio's Ski7 paper accepted in PlosGenetics | 18 Feb 2021
- Anna got into Oxford University for her PhD! | 05 Feb 2021
- Welcome to our new interns Anna (Bandura) and Lisa | 01 Feb 2021
- Bye-bye to Friederike, Mirjam and Sara | 29 Jan 2021
- Dr. Quio! | 27 Nov 2020
- Pumpkin-carving & Halloween | 31 Oct 2020
- Benni got his Master! | 21 Oct 2020
- Welcome to our new students Theresa, Anna and Sara! | 01 Oct 2020
- Pauli lab retreat - not in Corona after all :-) | 24 Sep 2020
- A quick, easy and open-source SARS-CoV-2 test | 25 Jul 2020
- Welcome to our interns Mirjam, Lena, and Lorena! | 01 Jul 2020
- HFSP postdoc fellowship for Victoria | 26 Mar 2020
- HFSP Young Investigator Award | 26 Mar 2020
Pauli Lab September 2019