Pauli Lab - from Fertilization to Cellular Remodelling

Research focus

The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:

  1. Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
  2. Translational regulation: We are interested in investigating translational regulation during embryogenesis.
  3. Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?

Our approach

To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.

Learn more …

Publications …

Science sketch

News ticker

  • DevStem Symposium at the IST | 03 Mar 2023
  • Welcome on board to our 4 international master students | 01 Mar 2023
  • A very special Pauli lab beer hour | 17 Feb 2023
  • Frieda at Weizmann Institute Embryo conference | 13 Feb 2023
  • SLAMseq paper published in Cell Reports | 08 Feb 2023
  • Ribosome paper published in Nature | 18 Jan 2023
  • Happy New Year from the Pauli lab | 31 Dec 2022
  • RNAclub social at Vienna Christmas market | 19 Dec 2022
  • IMP/IMBA Christmas party | 15 Dec 2022
  • Goodbye to our Master student Hannah | 07 Dec 2022
  • End-of-the-year celebration | 06 Dec 2022
  • Welcome to Lalitha | 15 Oct 2022
  • Germ Cells meeting in CSHL - and horseshoe crabs | 12 Oct 2022
  • Pauli lab retreat in Eisenerz | 26 Sep 2022
  • ERC Consolidator beer hour | 09 Sep 2022
  • Goodbye dinner with our students Clara and Fatma | 26 Aug 2022
  • Pauli & Obenauf Lab outing in the Prater | 10 Aug 2022

Learn more ….

About us

Pauli Lab members

Pauli Lab May 2022

Learn more …

Contact us

The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).

Learn more …

Funding

* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships