Research focus
The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Dormancy: We are interested in investigating the mechanisms of dormancy in the egg and during embryogenesis, with a particular focus on translational regulation.
Our approach
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
News ticker
- Goodbye to Gabi | 10 Jun 2026
- Welcome to Mia, our 'Talents for Future' student | 01 Jun 2026
- Goodbye to Hanna | 29 May 2026
- Victoria awarded IBSA fellowship | 28 May 2026
- Pauli lab moves one floor up | 21 May 2026
- New preprint about SPARK on bioRxiv! | 16 May 2026
- Theresa and Gabi at the Ubiquitin & Friends symposium | 29 Apr 2026
- Congrats to Sebastian for defending his Masters thesis | 28 Apr 2026
- Pauli lab at the Long Night of Research | 24 Apr 2026
- Tommaso Cavazza visits the IMP | 16 Apr 2026
- Paper about SMIM26 published in Genes & Development | 16 Apr 2026
- Biochemical Society Award for Laura | 14 Apr 2026
- Ambassador of El Salvador in Austria visits Pauli lab and IMP | 08 Apr 2026
- Welcome to Master Student Annaelle | 01 Apr 2026
- FWF emerging fields grant for project GEMINI | 10 Mar 2026
- Welcome to our internship student Gabi | 01 Mar 2026
- Ezra awarded a Marie Skłodowska-Curie Postdoctoral Fellowship fellowship | 17 Feb 2026
About us
10-years Pauli Lab, September 2025
Contact us
The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).
Links
Science sketch and videos
Funding
* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships
