The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- SPACA4 paper published in PNAS | 24 Sep 2021
- All the best to Eduardo | 31 Aug 2021
- Goodbye to our VBC summer student Mireia | 30 Aug 2021
- Annual Review about Sperm-Egg Fusion | 26 Jul 2021
- Salvadoran internship program in the Pauli lab | 21 Jul 2021
- Welcome to Mireia, our VBC Summer Student | 01 Jul 2021
- Christine Beattie Award from IZFS for Jessica | 22 Jun 2021
- BBQ at Andi's | 21 Jun 2021
- Andi elected as EMBO Member | 08 Jun 2021
- First post-Covid-lockdown drinks | 04 Jun 2021
- 1st Prize PhD student talk for Frieda at MicroSymposium | 23 Apr 2021
- Jessica's review on self-organized cell migration published in Development | 06 Apr 2021
- Spring is here! | 31 Mar 2021
- Bye-bye to Anna | 31 Mar 2021
- Welcome to Ziya | 01 Mar 2021
- Quio's Ski7 paper accepted in PlosGenetics | 18 Feb 2021
- Anna got into Oxford University for her PhD! | 05 Feb 2021
Pauli Lab June 2021