Research focus
The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
Our approach
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
Science sketch
News ticker
- Welcome to Johannes | 01 Oct 2023
- Collaborative paper on DNA methylation in zebrafish-medaka hybrids published in NAR | 26 Aug 2023
- Frieda defends her PhD | 25 Aug 2023
- Catch-up in Woods Hole | 29 Jul 2023
- New pre-print by Victoria & Andreas on sperm fertilization factors forming a trimer | 29 Jul 2023
- Pauli lab at the GRC Fertilization | 25 Jul 2023
- Krista defends her PhD | 19 Jun 2023
- Krista's Bouncer match-maker paper out in NatureCommunications! | 14 Jun 2023
- New pre-print by Laura on eIF4E1b | 11 Jun 2023
- Collaborative hybrid paper on bioRxiv | 24 May 2023
- Andi with LAMP team in Ghana | 18 Apr 2023
- DevStem Symposium at the IST | 03 Mar 2023
- Welcome on board to our 4 international master students | 01 Mar 2023
- A very special Pauli lab beer hour | 17 Feb 2023
- Frieda at Weizmann Institute Embryo conference | 13 Feb 2023
- SLAMseq paper published in Cell Reports | 08 Feb 2023
- Ribosome paper published in Nature | 18 Jan 2023
About us
Pauli Lab May 2022
Contact us
The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).
Links
Funding
* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships
