The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- DevStem Symposium at the IST | 03 Mar 2023
- Welcome on board to our 4 international master students | 01 Mar 2023
- A very special Pauli lab beer hour | 17 Feb 2023
- Frieda at Weizmann Institute Embryo conference | 13 Feb 2023
- SLAMseq paper published in Cell Reports | 08 Feb 2023
- Ribosome paper published in Nature | 18 Jan 2023
- Happy New Year from the Pauli lab | 31 Dec 2022
- RNAclub social at Vienna Christmas market | 19 Dec 2022
- IMP/IMBA Christmas party | 15 Dec 2022
- Goodbye to our Master student Hannah | 07 Dec 2022
- End-of-the-year celebration | 06 Dec 2022
- Welcome to Lalitha | 15 Oct 2022
- Germ Cells meeting in CSHL - and horseshoe crabs | 12 Oct 2022
- Pauli lab retreat in Eisenerz | 26 Sep 2022
- ERC Consolidator beer hour | 09 Sep 2022
- Goodbye dinner with our students Clara and Fatma | 26 Aug 2022
- Pauli & Obenauf Lab outing in the Prater | 10 Aug 2022
Pauli Lab May 2022
The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).
* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships