The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Translational regulation: We are interested in investigating translational regulation during embryogenesis.
- Toddler: How does the short, secreted protein Toddler/Apela regulate gastrulation movements?
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
- Welcome to Johannes | 01 Oct 2023
- Collaborative paper on DNA methylation in zebrafish-medaka hybrids published in NAR | 26 Aug 2023
- Frieda defends her PhD | 25 Aug 2023
- Catch-up in Woods Hole | 29 Jul 2023
- New pre-print by Victoria & Andreas on sperm fertilization factors forming a trimer | 29 Jul 2023
- Pauli lab at the GRC Fertilization | 25 Jul 2023
- Krista defends her PhD | 19 Jun 2023
- Krista's Bouncer match-maker paper out in NatureCommunications! | 14 Jun 2023
- New pre-print by Laura on eIF4E1b | 11 Jun 2023
- Collaborative hybrid paper on bioRxiv | 24 May 2023
- Andi with LAMP team in Ghana | 18 Apr 2023
- DevStem Symposium at the IST | 03 Mar 2023
- Welcome on board to our 4 international master students | 01 Mar 2023
- A very special Pauli lab beer hour | 17 Feb 2023
- Frieda at Weizmann Institute Embryo conference | 13 Feb 2023
- SLAMseq paper published in Cell Reports | 08 Feb 2023
- Ribosome paper published in Nature | 18 Jan 2023
Pauli Lab May 2022