Research focus
The long-term vision of the Pauli lab is to unravel new concepts and molecular principles governing one of the most dramatic developmental transitions, the oocyte-to-embryo transition. Our current research is centered around the following topics:
- Fertilization: How is fertilization regulated? We are specifically interested in identifying new molecular players and gain mechanistic insights into sperm-egg interaction and fusion.
- Dormancy: We are interested in investigating the mechanisms of dormancy in the egg and during embryogenesis, with a particular focus on translational regulation.
Our approach
To address these questions, we are mainly using zebrafish embryos since they are a powerful model of vertebrate embryogenesis. We combine various approaches, ranging from genetics, molecular and cell biology, biochemistry and structural biology to live cell imaging, genomics and evolutionary analyses.
News ticker
- Pauli Lab members at the zebrafish course in Woods Hole | 06 Aug 2025
- Johannes and Victoria attend the 2025 GRC on Fertilization and Activation of Development | 28 Jul 2025
- Lab retreat in Styria - first annual PAULIs! | 18 Jul 2025
- Johannes awarded DOC PhD Fellowship | 15 Jul 2025
- Andi and Victoria attend the Fertility - Contribution of Maternal Inheritance Meeting in Paris | 18 Jun 2025
- Ida and Romane go on field trip to Brno | 06 Jun 2025
- Ida at the 2025 Nothobranchius symposium in Jena | 06 Jun 2025
- Victoria receives the 2025 Chi-Bin Chien Award from IZFS | 03 Jun 2025
- Aleq joins the Pauli lab as a Talents-for-Future summer student | 01 Jun 2025
- Running for a cause - Pauli lab at Wings for Life World Run | 04 May 2025
- Victoria attends the 2025 National Contraception Meeting and MIT Catalyst Symposium | 30 Apr 2025
- Ida awarded a HFSP postdoctoral fellowship | 04 Apr 2025
- The Pauli lab welcomes Romane and Lucie | 01 Apr 2025
- Fertilization Team Visits Ikawa Lab in Osaka | 10 Feb 2025
- Bye-bye to Sarah and Auwal | 29 Jan 2025
- Andreas defends his PhD | 27 Jan 2025
- 2024 - a year in pictures | 01 Jan 2025
About us
Pauli Lab May 2022
Contact us
The lab is based at the Research Institute of Molecular Pathology (IMP), a basic research institute that is part of the Vienna Biocenter (VBC).
Links
Science sketch and videos
Funding
* Research Institute of Molecular Pathology (IMP) * Boehringer Ingelheim (BI) * European Research Council (ERC) * FWF START Grant (2017-2023) * FFG * HFSP Career Development Award (2016-2020), HFSP Young Investigator Grant (2020-2022) * EMBO-YIP (EMBO Young Investigator Programme) * Boehringer Ingelheim Fonds (2016-2018; 2021-2023) * Austrian Academy of Sciences (ÖAW) * FNSNF (Swiss National Science Foundation) * EMBO postdoc fellowship * RNA Society (RNA Salon) * SFB RNA-Deco (FWF) * Marie Sklodowska-Curie Individual Fellowships
